The stated rationale was safety concerns, though many clinicians and compounding pharmacy groups argued the agency overstepped, noting that no specific safety signal justified the restriction for most of the affected peptides
The upregulation of growth hormone receptors also explains why penta deca peptide arginate pairs so well with growth hormone secretagogues in stacking protocols
John Wilding, professor of medicine in the Department of Cardiovascular and Metabolic Medicine at the University of Liverpool, said this was unsurprising, adding: Obesity is a chronic disease that usually relapses when treatment is stopped. Tricia Tan, professor of metabolic medicine, diabetes and endocrinology at Imperial College London/Imperial College Healthcare NHS Trust, said: There is increasing evidence that structured exercise is important to prevent weight regain after cessation of weight-loss drugs, but noted that this was not discussed in the study
Another significant nutritional aspect of durian pulp is its outstanding antioxidant properties, which are primarily attributed to its high polyphenol content 26
Losing muscle lowers your resting metabolic rate, making it harder to keep weight off long-term
The EMA does not list kidney damage as a common side effect, but its guidance is similar to the FDAs: pay close attention to hydration and kidney function during tirzepatide treatment
